Scientific Modulation of the Gut-Liver Axis for Next-Generation Metabolic Health

The Global Challenge

Modern lifestyles—long working hours, irregular schedules, high stress, and frequent social dining—have placed a growing burden on the liver and metabolic system. The World Health Organization (WHO) identifies chronic liver disease and metabolic dysfunction as global public health priorities, driving consumer demand for safe, natural, and science-backed solutions.
 

Unlocking the Gut-Liver Axis

• Microbiota balance drives metabolism: Gut microbes regulate the conversion of primary to secondary bile acids, a key step for lipid breakdown and energy metabolism.
• Disrupted cycles: Dysbiosis interferes with fat and sugar metabolism, contributing to uric acid imbalance and metabolic overload on the liver.
• Healthy gut, resilient liver: Supporting the gut microbiota is a central strategy for maintaining liver function and overall metabolic efficiency.

Clinically Studied & Patented Probiotic Blend

PRONULIFE^® LvUCare is a proprietary probiotic combination, designed to address modern metabolic challenges by supporting gut-liver axis health.

Formulation Information

Product	Probiotic Strains
PRONULIFE® LvUCare	L. fermentum TSF331                    L. reuteri TSR332 L. plantarum TSP05

🔬 Scientific Support

• Purine metabolism: Shown to support purine breakdown in the gut, helping maintain healthy uric acid levels.
• Liver resilience: Animal studies demonstrate reduced triglyceride accumulation under alcohol-induced stress, supporting liver health.
• Microbiome balance: Modulates gut ecology to reduce inflammatory burden, supporting coordinated liver-kidney function.

Key Advantages of PRONULIFE® LvUCare

• Comprehensive Metabolic Support: Addresses interconnected pathways of liver, gut, and uric acid metabolism.
• Validated by Science: Supported by both preclinical and clinical research, ensuring reliable efficacy.
• Patented Innovation: Protected by TW I764598 and international applications, securing its unique mechanism in purine metabolism regulation.
• Versatile Applications: Suitable for dietary supplements and functional foods designed for modern lifestyle health.

Patent

• TW I764598｜Application of Lactobacillus plantarum TSP05 in reducing purine content and maintaining uric acid balance

📩 For technical data, customization inquiries, or formulation partnerships, contact us at
📧 glac@glac.com.tw
Further Reading: PRONULIFE® Functional Probiotic Ingredients 🔙
  

【References】

1. WHO NCDs.
2. Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy
3. Global Fatty Liver Day 2025: Elevating Liver Health in the Metabolic Health Conversation – Global Liver Institute
4. Metagenomic analysis revealed the potential role of gut microbiome in gout. npj Biofilms and Microbiomes 2021, 7(1), 1-13.
5. The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota. Alcohol Res. 2015;37(2):223-36.
6. Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats
7. Lactobacillus spp. reduces ethanol-induced liver oxidative stress and inflammation in a mouse model of alcoholic steatohepatitis