Irreversible Oral Problems — Why Oral Probiotics Are Needed

According to research from the World Health Organization (WHO):

• Nearly half of the global population (approx.3.5 billion people / 45%) suffer from oral and dental diseases
• The most common conditions includedental caries (tooth decay), periodontal disease, tooth loss, and oral cancer
• Untreated dental cariesis the most prevalent disease worldwide, affecting over2.5 billion people
• Approximately19% of adultsworldwide suffer from severe periodontal disease, with over1 billion cases

While most oral diseases can be prevented through daily health care, once developed, they are often irreversible and lifelong.
Incorporating probiotics into daily oral care is a proactive way to support oral health,
helping to maintain a healthy smile while boosting inner confidence.

Common Oral Pathogens

• Caries pathogen:
  • Streptococcus mutans
    Adheres to teeth, forms biofilm, metabolizes sugars, and causes cavities.
• Periodontal pathogens:
  • Porphyromonas gingivalis
  • Fusobacterium nucleatum 
  • Aggregatibacter actinomycetemcomitans

Release toxins that trigger immune responses and cytokine release,
leading to alveolar bone and periodontal tissue destruction.

Creating an “Invisible Mask” for Oral Defense — Probiotic Solutions

The Glac R&D Center has screened premium oral probiotic strains from its extensive strain library, and clinical studies demonstrate multiple health benefits:

• Inhibits the growth of common oral pathogens
• Reduces cariogenic bacteria while increasing beneficial oral probiotics
• Enhances Immunoglobulin A (IgA) production
• Improves oral microbiota environment (validated through NGS analysis)
• Supports oral immune functions and daily protection

Research further confirms that probiotics and postbiotics (Totipro^® Postbiotics) both show excellent effects.

Functional Probiotic Blends

Formula	Strain Composition
PRONULIFE® OraProtect	L. salivarius AP-32 B. animalis subsp. lactis CP-9 L. paracasei ET-66
PRONULIFE® OraProtect-L	L. paracasei ET-66 L. salivarius AP-32 L. plantarum LPL-28

Patent Support

• TW I639389: Food, oral care, and pharmaceutical compositions containing Lactobacillus strains for inhibiting oral pathogens
• CN ZL2017111555468.8: Food, oral care, and pharmaceutical compositions containing Lactobacillus strains for inhibiting oral pathogens

The PRONULIFE^® OraProtect series provides comprehensive oral health support through synergistic multi-strain formulations.
Combining Glac’s patented technologies with clinical validation,
it delivers safe, science-based,
and competitive solutions for brand owners and ODM/OEM partners.
📧 Contact us: glac@glac.com.tw Further Reading: PRONULIFE® Functional Probiotic Ingredients🔙

References

1. Heat-killed lactic acid bacteria enhance immunomodulatory potential by skewing the immune response toward Th1 polarization.J Food Sci. 2011;76(5):260-267.
2. The potential for probiotics to modulate inflammation of oral and throat by in vitro and animal model. The 6th Asian Conference on Lactic Acid Bacteria. 2011. P-AM11-78. P68.
3. Potential of probiotic strains to modulate the inflammatory responses of epithelial and immune cells in vitro. New Microbiologica. 2013;36:167-179.
4. Lactobacillus candidate strains have advantages on oral sterilization and might have whitening effectiveness. AFSLAB International Symposium. 2016.
5. Functional characterization and application of probiotic strains for oral health care. CIFST Annual Meeting. 2018.
6. Antibacterial activity of viable and heat-killed probiotic strains against oral pathogens. Lett Appl Microbiol. 2020.
7. Lozenges with probiotic strains enhance oral immune response and health. Oral Diseases. 2021.
8. Viable and heat-killed probiotic strains improve oral immunity by elevating IgA concentration in the oral mucosa. Current Microbiology. 2021:1–9.